Harness the power of next-generation sequencing for forensic genomics work

Forensic Genomics Applications

Targeted sequencing of the genes used for human identification can inform forensic DNA testing and deliver more conclusive results for criminal casework, missing persons cases, or disaster victim identification. Because of the complex nature and large numbers of biological samples at the heart of these applications, analytical capabilities must be robust, reliable, and scalable.

Today, most forensic DNA testing utilizes PCR and capillary electrophoresis (CE)-based methods for the analysis of forensic samples. However, numerous limitations in that approach exist, including challenges presented by degraded DNA, low quantity DNA, or complex DNA mixtures, which can result in a forensic case going unresolved.

Currently database laboratories often must perform multiple reactions to type all loci they desire. Illumina sequencing by synthesis (SBS) technology offers a massively parallel approach for sequencing PCR amplicons and allows forensic scientists worldwide to harness the full power of targeted next-generation sequencing (NGS).

Using contemporary forensic genomics, examiners can generate data that span the human genome and address a wider range of questions in a single, targeted assay. NGS-generated STR allele calls are fully compatible with current database formats, providing a seamless link between CE-based and NGS data.

Targeted NGS for Forensic Genomics

Get an intro to next-generation sequencing and its applications for forensic genomics.

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Criminal Casework

Targeted sequencing of forensically relevant STR and SNP loci empowers you to generate leads, even on cold cases. With NGS, crime laboratories can address hundreds of markers in a single test. This lets labs develop a more thorough, detailed profile from degraded, mixed, and limited DNA samples.

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Forensic DNA Databases

Millions of DNA profiles are curated in national DNA databases. NGS can help labs produce high-quality forensic DNA profiles more efficiently. Because Illumina sequencing technology analyzes multiple marker sets simultaneously, rather than sequentially, there is a faster turnaround.

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Disaster Victim Identification

The goal of genetic analysis of evidence from a mass fatality is to extract as much information as possible from highly compromised samples. NGS sets no relevant limit on the number of loci you can analyze in one test. Achieve high resolution and exceptional accuracy from as little as 1 ng of DNA.

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Identifying Missing Persons

Illumina SBS offers a massively parallel approach for sequencing forensic PCR amplicons, both nuclear and mitochondrial. NGS enables scientists to utilize a single platform and optimal workflow to overcome the widest range of difficult samples often encountered in missing persons cases.

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