Infinium Global Diversity Array with Cytogenetics-8

Profile clinical research variants associated with congenital disease, cancer research, pharmacogenomics (PGx), and exome content with this microarray. Read More...
Select Product(s)

Infinium GDACyto-8 v1.0 Kit, 16 Sample (Includes array and consumables)

20066507

Infinium GDACyto-8 v1.0 Kit, 48 Sample (Includes array and consumables)

20066508

Infinium GDACyto-8 v1.0 Kit, 96 Sample (Includes array and consumables)

20066509

Infinium GDACyto-8 v1.0 Kit, 384 Sample (Includes array and consumables)

20066510

Services

Infinium® Assay: An Introduction – Customer Site

20015273

Product Highlights

The Infinium Global Diversity Array with Cytogenetics-8 is a scalable, cost-effective microarray that contains approximately 1.8M probes, with 160K probes supplementing the current Global Diversity Array manifest across more than 4800 tiered genes. Supplemental probes were selected based on the input from a cytogenetics research consortium and strategically localized near exons, in spatial consideration of existing probe placement, to deliver optimal performance in copy number variation analysis.

  • Detect structural variation in the human genome, including duplications, deletions, amplifications, copy-neutral loss of heterozygosity, and mosaicism.
  • Examine cytogenomic changes in constitutional diseases, cancers, and more.
  • Process sample types including saliva, blood, and buccal swabs using the PCR-free Infinium HD Assay with only 200 ng DNA per sample.
  • Analyze formalin-fixed paraffin-embedded (FFPE) paired tumor-normal samples when used with the appropriate FFPE cluster file.
Broad Clinical Research Applications

Markers were selected from clinical research databases, including ClinVar, CPIC, and PharmGKB for research applications, including risk profiling, pharmacogenomics, wellness characterization, and disease discovery.

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Specifications

Product Comparison

Infinium Global Diversity Array with Cytogenetics-8 Infinium Global Diversity Array-8 Kit Infinium CytoSNP-850K v1.3 BeadChip
Assay Time 3 days 3 days
Automation Capability Automated Array Loader, Liquid Handling Robots Automated Array Loader, Liquid Handling Robots Automated Array Loader, Liquid Handling Robots
Cancer Type Hematologic, Solid Tumor Hematologic, Solid Tumor Hematologic, Solid Tumor
Description The 8-sample Infinium Global Diversity Array with Cytogenetics-8 provides extensive targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb. The 8-sample Infinium Diversity Array provides targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb. The 8-sample Infinium CytoSNP-850K v1.2 BeadChip provides disease-focused coverage of 3262 genes of known cytogenetics relevance in both constitutional and cancer applications. The BeadChip content includes approximately 850K empirically selected variant markers spanning the genome with supplemental coverage for cytogenetic applications.
Hands-On Time 1 hour and 5 minutes for automated 8-beadchip workflow 1 hour 5 min. for automated 8-beadchip workflow, 6 hours 15 min. for manual 8-beadchip workflow
System Compatibility iScan iScan HiScan, iScan, NextSeq 550
Technology Microarray Microarray Microarray
Variant Class Chromosomal Abnormalities, Copy Number Variants (CNVs), Loss of Heterozygosity (LOH), Single Nucleotide Polymorphisms (SNPs) Chromosomal Abnormalities, Copy Number Variants (CNVs), Loss of Heterozygosity (LOH), Single Nucleotide Polymorphisms (SNPs) Chromosomal Abnormalities, Copy Number Variants (CNVs), Loss of Heterozygosity (LOH), Single Nucleotide Polymorphisms (SNPs)

High-Level Workflow

Case Studies

Exploring variants of unknown significance with cytogenetic microarrays

The Infinium™ Global Diversity Array with Cytogenetics-8 BeadChip provides accurate analysis of gene structure and numerical variation

Read More

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