Multiomics (multiple omics) provides an integrated perspective to power discovery across multiple levels of biology. This biological analysis approach combines genomic data with data from other modalities such as transcriptomics, epigenetics, and proteomics, to measure gene expression, gene activation, and protein levels.
Multiomics profiling studies enable a more comprehensive understanding of molecular changes contributing to normal development, cellular response, and disease. Using integrative omics technologies, researchers can better connect genotype to phenotype and fuel the discovery of novel drug targets and biomarkers.
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Multiomics offers the following benefits:
Multiomics is also becoming more accessible. The cost of high-throughput sequencing (price/Gb) has decreased by >90% over the past decade. At the same time, grant funding has increased for multiomic studies (since 2012, there has been a 48% average year-over-year increase in the number of active or starting grants for multiomics studies).
Incorporating RNA-Seq can help researchers annotate and prioritize variants for functional analysis to understand mechanisms of disease. A multiomics approach to functional genomics can help power drug target identification and biomarker discovery.
Comprehensive epigenetic profiling can reveal patterns of gene regulation to help find the function of variants identified by GWAS. Multiomics approaches that combine methylation or other epigenetic profiling with genetic information can connect functional layers to decipher complex pathways and disease mechanisms.
The integration of genomics plus epigenetics and RNA-Seq can help researchers identify candidate genes and understand the mechanisms controlling interesting phenotypes. This holistic, non-biased multiomics approach can uncover new regulatory elements for biomarkers and therapeutic targets.
Incorporating protein detection with RNA-Seq can tie new discoveries back to known canonical markers and historical clinical outcomes. When cell surface markers are more robustly analyzed through multiomics, there are more chances to catch a signal that is important to you.
This multiomic approach directly connects genotype to phenotype for more informed research on disease and therapeutics development. Linking genetic variation to protein expression at the single-cell level can reveal the functional impact of somatic mutations on human cancers to better understand tumor evolution and disease progression.
Learn how researchers uncovered novel diagnostic and therapeutic targets for common chronic diseases by integrating imaging, genomics, transcriptomics, epigenetics, and big data.Read Interview
Multiomics sequencing is a powerful approach for evaluating variant effects through measurement of multiple layers of information.
Discusses how approaches for epigenetics analyses and other omics can be used and integrated to examine different levels of genome activity in tissues and cells.
There are many potential omics-based precision medicine applications within large academic medical centers, ranging from planning a baby to molecular autopsy.
Cancers are complex, necessitating genomic, transcriptomic, epigenetic and proteomic characterization. Multiomics offers the sensitivity to potentially detect rare variants and provide more data in less time.
Single-cell multiomics analysis illuminates how genes are expressed and regulated across different cell types. Integrated multiomic data sets can deepen our understanding of cellular phenotypes.
A multiomics approach can uncover deeper biological context to disease-causing variants and accelerate our understanding of common disorders, unlock new pathways, biomarkers, and drug targets.