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Fungi identify the geographic region of dust samples.


Researchers pinpointed the origin of dust samples by sequencing geographically endemic fungal species found in the dust. This represents a new, faster approach in forensic biology to determine the origin of dust or soil samples, compared to traditional pollen-based methods.

Read more at PubMed »

 
 
Fungi identify the geographic region of dust samples.
 
 
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.
 
 
In-depth study of Mollivirus sibericum, a new 30,000-y-old giant virus infecting Acnathamoeba.
 
 
Height reducing variants and selection for short stature in Sardinia.
 
 

Fungi identify the geographic region of dust samples.

Researchers pinpointed the origin of dust samples by sequencing geographically endemic fungal species found in the dust. This represents a new, faster approach in forensic biology to determine the origin of dust or soil samples, compared to traditional pollen-based methods.

Read more at PubMed »

Grantham NS, Reich BJ, Pacifici K, et al. Fungi identify the geographic region of dust samples. - PLoS One

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

Heritable genetic variants that affect bone mineral density (BMD) are associated with osteoporosis and osteoporotic (low-trauma) bone fractures. Researchers sequenced osteoporosis-associated genetic variants. One novel, rare variant was discovered near the gene EN1. This data and supporting animal studies indicate that EN1 is important in bone physiology.

Read more at PubMed »

Zheng HF, Forgetta V, Hsu YH, et al. Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. - Nature

In-depth study of Mollivirus sibericum, a new 30,000-y-old giant virus infecting Acnathamoeba.

Researchers sequenced a new type of giant virus (~ 0.5 µM in diameter) they revived from a 30,000 year-old sample of permafrost. Their work suggests prehistoric live viruses are not rare and require consideration in the face of global warming.

Read more at PubMed »

Legendre M, Lartigue A, Bertaux L, et al. In-depth study of Mollivirus sibericum, a new 30,000-y-old giant virus infecting Acnathamoeba. - Proc Natl Acad Sci USA

Height reducing variants and selection for short stature in Sardinia.

Human height is a complex heritable trait. Population-level effects of rare genetic variants on height are still largely unknown. Researchers used Illumina array and sequencing technology to study the island population of Sardinia, who are among the shortest in Europe. They found several variants common to Sardinians, but rare in other Europeans, that cause significant reductions in height.

Read more at PubMed »

Zoledziewska M, Sidore C, Chiang CW, et al. Height redusing variants and selection for short stature in Sardinia. - Nature Genetics

Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.

Researchers sequenced hundreds of cancer and normal samples in parallel. They found that despite multiple physical barriers, mitochondrial-nuclear genome fusion occurs at a rate similar to chromosomal rearrangements in the nuclei of cancer cells. Replication-dependent DNA double-strand break repair is the dominant mechanism. These tumorigenic events may occur in normal somatic cells.

Read more at PubMed »

Ju YS, Tubio JM, Mifsud W, et al. Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells. - Genome Research