Comparison Table
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| TruSight Tumor 170 | TruSight RNA Fusion Panel | AmpliSeq for Illumina Focus Panel | AmpliSeq for Illumina Comprehensive Cancer v3 | |
|---|---|---|---|---|
| Description | Comprehensive somatic mutation detection in solid tumors. Uses variant calling information from both DNA and RNA. | Gene fusion detection with known and novel partners in 507 fusion associated genes. Simplified analysis solution reports all detected fusions. | Somatic analysis of genes associated with solid tumor cancers, simultaneously assaying DNA and RNA. | Somatic analysis of genes associated with solid tumor cancers. |
| Design | Fixed set of probes that enrich for full coding sequences of 170 genes. Single nucleotide variants, small insertions, and deletions are called in 151 genes; amplifications are called in 59 genes; fusions and splice variants are called in 55 genes. | Gene fusion panel targeting 507 cancer-associated fusion gens and 7690 exons | Hotspots and full-length targets of 52 genes. | Hotspots and full length targets of 161 genes |
| Targeted Region | 533 kb DNA 358 kb RNA |
507 genes | 29 kb DNA 26 kb RNA |
397 kb DNA 86 kb RNA |
| Method | Enrichment | Enrichment | Amplicon | Amplicon |
| Input (total RNA) | 40–80ng FFPE RNA 40–120ng FFPE DNA |
10 ng for high quality RNA 20–100 ng for FFPE |
10ng recommended | 10ng recommended |
| FFPE Compatible | Yes | Yes | Yes | Yes |