The Infinium Global Screening Array-24 v3.0 BeadChip combines multi-ethnic genome-wide content, curated clinical research variants, and quality control (QC) markers for precision medicine research.
The genome-wide content was selected for high imputation accuracy at minor allele frequencies of >1% across all 26 1000 Genomes Project populations. The clinical research content includes variants with established disease associations, relevant pharmacogenomics markers, and curated exonic content based on ClinVar, NHGRI, PharmGKB, and ExAC databases. QC content enables sample identification and tracking for large-scale genomics and screening applications.
With over 15 million samples worth of BeadChips sold, the Global Screening Array's global adoption provides a network of human disease researchers, healthcare networks, consumer genomics companies, and genomic service providers to help power discovery.
The array provides a genomic tool for clinical research applications including disease risk profiling studies, pharmacogenomics research, wellness characterization, and complex disease discovery.
Version 3 of the Global Screening Array leverages the most up to date and relevant clinical research screening markers derived from ClinVar, CPIC, and PharmGKB.
As leading databases such as ClinVar continue to rapidly add new variants, Illumina is dedicated to ensuring the variants interrogated on the GSA remain updated and relevant. The launch of the Infinium GSA-24 v3.0 BeadChip includes an update of key variants found in ACMG 59 genes. A growing number of precision medicine research initiatives around the world are leveraging these variants to screen populations for the following applications:
The array supports genotyping and CNV calling for sample types including saliva, blood, and buccal swabs. The format also enables processing of thousands of samples per week with a 3-day workflow for population-scale studies.
Infinium Global Screening Array-24 Kit | Infinium Omni2.5-8 Kit | |
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Description | An economical next-generation genotyping array that enables population-scale genetics, translational research, variant screening studies, and precision medicine research by combining highly optimized multiethnic genome-wide content, curated clinical research variants, and QC markers. | 8-sample arrays with high throughput and optimized tag SNP content, including full support of copy number variation applications, designed to be highly customizable and maximally informative for studying diverse world populations. |
Nucleic Acid Type | DNA | DNA |
Number of Markers | Fixed markers: ~ 640,000 Custom marker add-on capacity: Up to 50,000 |
Fixed markers: 2,372,784 Custom marker add-on capacity: Up to 200,000, Custom marker add-on capacity: None |
Number of Samples | 24 samples per array | 8 samples per array |
Species Category | Human | Human |
Technology | Microarray | Microarray |
Fast Infinium array analysis and broad genome coverage support personal genetic testing services and database development.
Read InterivewMyDNA recently began partnering with Illumina customers using the Global Screening Array and Asian Screening Array in their genetic test offerings.
Read InterviewSano Genetics connects researchers with valuable information about rare disorders while protecting individual's privacy.
Read InterviewThe Global Screening Array and iScan System are helping Mapmygenome bring consumer genomics to a rapidly growing Indian population.
Read ArticleData Sheet | PDF | 5 versions
Infinium HTS Assay Reference Guide Documentation
Infinium Assay Consumables and Equipment List Documentation
Infinium HTS Assay Auto Workflow Checklist Documentation
Infinium HTS Automated Lab Tracking Form (15047410) Documentation
Infinium HTS Assay Manual Workflow Checklist Documentation
Infinium HTS Assay Manual Lab Tracking Form (15047409) Documentation