Chosen by the All of Us research program
The GDA is the commercial version of the array chosen by the All of Us Research Program. This program will engage one
million or more volunteers living in the U.S. to contribute their health data over many years to improve health
outcomes, fuel the
development of new treatments for disease, and catalyze a new era of evidence-based and more precise preventive care and
medical treatment. Moreover, one of the program's core values guiding development and implementation is for participants
to reflect the rich diversity of the U.S. The GDA was built to meet these needs by combining highly optimized
multi-ethnic, genome-wide content with curated clinical research variants.
Highly Informative Array that Maximizes Variant Coverage
The GDA provides the most cost effective variant coverage within the Illumina human array portfolio. This
8-sample BeadChip features exceptional, up-to-date coverage of clinical research variants associated with
disease and pharmacogenetics. The GDA is built on a high-density single nucleotide polymorphism (SNP) global
backbone optimized for cross-population imputation coverage of the genome. The GDA enables polygenic risk
score development and characterization of genetic architecture in diverse populations.
Multi-Ethnic Backbone Built through Collaboration with Leading Institutions
The GDA contains a robust genome-wide scaffold designed to tag both common and low frequency variants in
global populations. This scaffold was designed through collaborations with the Consortium on Asthma among
African-ancestry Populations in the Americas (CAAPA) and Population Architecture using Genomics and
Epidemiology (PAGE). The GDA includes content not found in 1K Genomes Project, with more than 1000
whole-genome sequences of African ancestry and populations throughout the Americas, including the US,
Caribbean, and Latin and South America.
Robust Assay and High-Throughput Workflow
The GDA uses the 8-sample Infinium LCG format which enables laboratories to scale efficiently as needed. For
flexible throughput processing, the Infinium LCG assay provides the capability to run up to 1728 samples per week using a single iScan System. The Infinium LCG assay provides a rapid,
three-day workflow that allows users to gather and report data quickly.