Beyond conventional cell and molecular biology research methods

NGS methods enable global analyses of gene expression and regulation

Cellular & Molecular Biology Research

Traditionally, cell and molecular biology research seeks to understand the function of a single gene, gene family, or signal transduction pathway, often through the disruption or modification of single genes. Researchers use signal-based methods such as microscopy, flow cytometry, and protein blotting and molecular assays such as PCR/qPCR, Sanger sequencing, and gene expression arrays. This approach is time-consuming and does not always result in conclusive findings.

Array and next-generation sequencing (NGS) technologies from Illumina can broaden cell and molecular biology research beyond the conventional methods of protein-interaction and single-gene functional studies. Illumina technology enables analysis across the genome, transcriptome, and epigenome. Results can inform experimental design and subsequent studies, saving time and allowing researchers to publish sooner.

NGS in Cell Biology Research

See how NGS offers new methods for expanding cell and molecular biology research.

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Compare the benefits of NGS technology to qPCR and learn which one to choose.

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Genetic Studies of Memory

Dr Matt Huentelman uses single-cell RNA sequencing to study the genetic and neurological variables affecting learning and memory.

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Single-Cell RNA Sequencing

Providing a high-resolution view of cell-to-cell variation for cellular and molecular biology research. This method allows you to explore the distinct biology of individual cells within a complex tissue, and understand subpopulation responses to environmental cues.

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SureCell Whole Transcriptome Analysis 3' Library Prep Kit: This kit supports transcriptome profiling of hundreds to tens of thousands of single cells in a given experiment.

NextSeq 550 System: This system combines sequencing and array scanning on a single platform.

BaseSpace Sequence Hub Single-Cell RNA-Seq App: Designed for use with the SureCell WTA 3' Library Prep Kit, this app performs cell and gene counting, filtering, and reporting.

AmpliSeq for Illumina Targeted Resequencing Solution:A streamlined, scalable amplicon sequencing solution, producing high-confidence data from low-input DNA and RNA samples.

Infinium Global Screening Array: A next-generation genotyping array for population-scale genetics, variant screening, pharmacogenomics studies, and precision medicine research.

MethylationEPIC BeadChip: Robust methylation profiling microarray with extensive coverage of CpG islands, genes, and enhancers. Use for epigenome-wide association studies.

From Genotype to Phenotype

Dr Lachlan Jolly discusses insights into gene function in cell models of brain development.

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Chan Zuckerberg Biohub and the NovaSeq System

Researchers at the Chan Zuckerberg Biohub are working to conduct innovative experiments and form new collaborations in genomics. The NovaSeq System enables them to bundle many samples together for medical research that may help to improve human health.

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Chan Zuckerberg Biohub and the NovaSeq System
Cellular Research Review
Cellular Research Review

This review highlights recent publications that used Illumina technology for single-cell sequencing.

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Simple, Customized RNA-Seq Workflows
Simple, Customized RNA-Seq Workflows

Evaluating RNA sequencing options for cellular and molecular biology research including single-cell RNA sequencing

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Mapping Neural Diversity with Single-Cell RNA-Seq
Mapping Neural Diversity with Single-Cell RNA-Seq

The ability to analyze gene expression signatures from individual cells is transforming the way neurons are classified.

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Software Tools to Simplify Data Analysis
Software Tools to Simplify Data Analysis

Illumina bioinformatics tools can help researchers manage, analyze, and interpret genomic data.

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