DRAGEN v4.2 Updates | New features include:
- Increased SNV and SV calling accuracy powered by an enhanced machine learning model and multigenome (graph).
- Improvements in small CNV calling accuracy with joint SV/CNV calling.
- Includes new targeted callers for carrier screening: HBA 1/2, CYP21A2, RHD/RHCE, and LPA.
- Additional information and full list of features can be found in the release notes.
Illumina DRAGEN Secondary Analysis
The Illumina DRAGEN Secondary Analysis provides accurate, comprehensive, and efficient analysis of next-generation sequencing data.
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製品の選択
On-Premise Server
合計：
製品のハイライト
DRAGEN analysis offers accurate, comprehensive, and efficient secondary analysis of next-generation sequencing data:
- Continuous Innovation: Graph reference genome and machine learning driving unprecedented accuracy2
- Hardware Acceleration: Provides ultra-efficient workflow; can fully process a 34x whole human genome in ~30 minutes with DRAGEN server v41
- Lossless Compression: Furthers ultra-efficient workflow by reducing FASTQ file sizes up to 5× with DRAGEN ORA (Original Read Archive)
- Broad Menu of Applications: Analyzes next-generation sequencing (NGS) data from whole genomes, exomes, methylomes, and transcriptomes
- Flexible Configurability: Available on platform of choice and scalable based on needs
DRAGEN analysis offerings
Key Benefits
Accurate results
99.83% accuracy score with the Precision FDA Truth Challenge V2 benchmark data.3
Comprehensive platform
Analyze whole genomes, exomes, methylomes, and transcriptomes with a single platform.
Efficient analysis
Process a 34x genome in ~ 30 minutes, with all supported callers2. Reduce FASTQ file sizes up to 5× with DRAGEN ORA Compression.
DRAGEN secondary analysis achieving award-winning accuracy
DRAGEN analysis leads in accuracy for germline and somatic variant calling demonstrated in industry challenges from precisionFDA.
Harness the power of DRAGEN analysis
DRAGEN analysis enables labs of all sizes and disciplines to do more with their genomic data. DRAGEN analysis uses highly reconfigurable field-programmable gate array technology (FPGA) to provide hardware-accelerated implementations of genomic analysis algorithms, such as BCL conversion, mapping, alignment, sorting, duplicate marking, and haplotype variant calling. DRAGEN ORA lossless genomic compression technology enables significant storage cost savings on FASTQ files. Fundamental features of DRAGEN analysis address common challenges in genomic analysis, such as lengthy compute times and massive volumes of data.
Without compromising accuracy, DRAGEN analysis delivers quickness, flexibility, and cost efficiency. The reprogrammable nature of DRAGEN analysis enables Illumina to develop custom algorithms and allows for improvements to accommodate future applications.
Key DRAGEN applications
| On-Premise Server | Onboard | On Illumina managed cloud platforms | |||
|---|---|---|---|---|---|
| NovaSeq X Series | NextSeq 1000/2000 | BaseSpace Sequence Hub | Illumina Connected Analytics | ||
| BCL Convert | Custom only | ||||
| DRAGEN ORA compression | |||||
| DRAGEN FASTQC + MultiQC | |||||
| Whole genome | Germline + Somatic | Germline only Somatic coming soon | Germline only | Germline + Somatic | Germline + Somatic |
| Enrichment (including Exome) | Germline + Somatic | Germline + Somatic | Germline + Somatic | Germline + Somatic | Germline + Somatic |
| DNA Amplicon | |||||
| RNA | |||||
| Single-Cell RNA | |||||
| Differential Expression | |||||
| NanoString GeoMx NGS | |||||
| RNA Amplicon | Coming soon | ||||
| Methylation | Coming H2 2023 | ||||
| Metagenomics | * | ||||
| RNA Pathogen Detection | |||||
| COVID | COVIDSeq, COVID lineage | Cloud only COVIDSeq | COVIDSeq, COVID lineage | ||
| TSO 500 | ctDNA available Solid Coming Soon |
Enabled in 3.10 |
|||
| Imputation | |||||
| ScATAC-Seq | |||||
| PGx Star Allele Caller | Coming soon | ||||
| Illumina Complete Long Reads | |||||
| DRAGEN Secondary Analysis for RPIP and UPIP panels | Beta | Beta | Beta | ||
*Metagenomics applications enabled by Kmer classifier, more tools coming soon
Core DRAGEN version varies across platforms, speak to a local representative for more information
SARS-CoV-2 NGS Data Toolkit
Illumina is making it simpler for researchers to detect and identify SARS-CoV-2 and contribute their findings to the community with an integrated software toolkit, free of charge.
Learn More
DRAGEN analysis on Illumina managed cloud platforms
DRAGEN analysis on Illumina Connected Analytics couples the accuracy and speed of the DRAGEN with the ability to customize analysis pipeline to operationalize informatics on a secure platform.
Learn about Illumina Connected Analytics
DRAGEN on BaseSpace Sequence Hub (BSSH) provides push button analysis capability in an intuitive, easy-to-use interface with compliance, and storage features of BaseSpace Sequence Hub and Amazon Web Services (AWS).
DRAGEN on-premise server
DRAGEN on-premise server offers highly accurate secondary analysis in a fraction of time compared with a traditional CPU-based system.
- Analyze and store data locally
- Supports varying levels of command line interface
- Replace up to 30 traditional compute instances
- Fully process a 34× whole human genome in ~30 minutes2. HG002 from PrecisionFDA truth challenge V2 run with DRAGEN analysis v4.0 on DRAGEN server v4, all callers
- One unit supports two NovaSeq 6000 Systems running at full capacity
DRAGEN onboard
DRAGEN onboard offers an accurate, comprehensive, and efficient secondary analysis solution for the NovaSeq X Series and NextSeq 1000/2000 Systems.
DRAGEN onboard NovaSeq X Series:
- Flexibly runs multiple secondary analysis pipelines in parallel.
- Performs up to four simultaneous applications per flow cell in a single run.
- Brings up to 5x lossless data compression, and analysis with supported applications
- Provides savings on analysis, which over five years can exceed the the price of the sequencer
Learn more about the NovaSeq X Series
DRAGEN onboard NextSeq 1000 and NextSeq 2000 Systems:
- Provides access to select DRAGEN analysis informatics pipelines
- Enables users to generate results in as little as two hours
- Uses intuitive pipeline algorithms to reduce reliance on external informatics experts
Customer Stories
Pioneering feline genetics with NGS
Basepaws, a Zoetis company, leverages the Illumina DRAGEN secondary analysis to develop direct-to-consumer DNA kits that provide cat owners with insights about their pets' health.
Read InterviewScaling to the cloud to support whole-genome sequencing
Kyle Retterer, MS, Chief Technology Officer of GeneDx, discusses use of DRAGEN in the cloud to scale computing and data storage. This evolution brought more data analysis speed, infrastructure security, cost efficiency, and simplicity to their data management.
Read Customer SpotlightBringing bioinformatics in-house reduces costs and turnaround time
Phosphorus uses DRAGEN secondary analysis to perform genomic data analysis onsite and at an accessible price point.
Read ArticleCan genomics stop cardiovascular disease?
Two DRAGEN servers help Cardio-CARE slay one petabyte of data to better understand heart disease in Hamburg.
DRAGEN analysis uses
DRAGEN analysis can be used in numerous fields in the biological sciences.
Genetic Diseases
Reduce time required for genomic analysis, with high accuracy and comprehensiveness
Oncology
Analyze tumor-only and tumor/normal samples with accuracy, comprehensiveness, and efficiency
Cell and Molecular Biology
Advance understanding of cellular mechanisms with rapid analysis pipelines for bulk and single cell samples
Population Genomics
Accurately and efficiently analyze sequenced genomes at scale. Accelerate re-analysis as computational tools improve over time
Infectious Disease
Detect and characterize infectious diseases with a comprehensive solution
Agrigenomics
Efficiently analyze animals and plants of varying genomic complexities with custom reference
References
- Illumina data on file, 2022.
- Illumina DRAGEN Secondary Analysis is the first single platform to achieve 99.83% accuracy based on PrecisionFDA v2 Truth Challenge Benchmark Data. Details here.
- PrecisionFDA Truth Challenge V2: Calling Variants from Short and Long Reads in Difficult-to-Map Regions. precision.fda.gov/challenges/10. Accessed November 3, 2020.
よく一緒に購入される製品
Flexible and Customizable Pipelines
DRAGEN analysis provides the flexibility to insert a variety of input files and produce a range of output documents. This flexibility enables users to customize their experience and use and produce their desired file format.
This diagram shows steps in the DRAGEN Germline Pipeline as an example. The actual steps vary for each pipeline.
製品資料
Basespace Sequencing Hub Apps Quick Guide
Brochure | PDF < 1 MB
Brochure | PDF < 1 MB
Tumor exome sequencing with Illumina DNA Prep with Enrichment and the DRAGEN Platform
Application Note | PDF 1 MB
Integrating the Illumina DRAGEN Bio-IT Platform within your Infrastructure
Technical Note | PDF < 1 MB
DRAGEN Bio-IT Platform on BaseSpace Sequence Hub
Data Sheet | PDF 1 MB
DRAGEN Germline Pipeline Specification Sheet
Data Sheet | HTML
High-resolution, high-throughput spatial transcriptomics of complex tissues
Application Note | PDF 3 MB
High-plex spatial proteogenomics of FFPE tissue sections
Application Note | PDF 2 MB
Application Note | PDF | 5 versions
Explore the transcriptome with single-cell resolution
Technical Note | PDF 1 MB
Technical Note | PDF | 3 versions
Technical Note | PDF | 2 versions
Data Sheet | PDF | 7 versions
BaseSpace Sequence Hub | クラウドベースのゲノムデータ管理
次世代シーケンサー（NGS）の運用を開始し、急速に拡大するラボのためのデータ管理および簡素化されたバイオインフォマティクス。
Illumina Connected Analytics
A secure genomic data platform to operationalize informatics and drive scientific insights.
