製品

Illumina DRAGEN Secondary Analysis

The Illumina DRAGEN Secondary Analysis provides accurate, comprehensive, and efficient analysis of next-generation sequencing data. 続きを読む...

この製品は出荷できる国が制限されています。 出荷の可否を確認するには、 出荷する国を選択してください 。

製品の選択
On-Premise Server

Illumina DRAGEN Server v4

20051343

価格
 
 

DRAGEN Server Lvl 1 1 year License

20060397

DRAGEN Server Lvl 2 1 year License

20060398

DRAGEN Server Lvl 3 1 year License

20060399

DRAGEN Server Lvl 4 1 year License

20060400

DRAGEN Server Lvl 5 1 year License

20060401

カートに追加
合計：

Illumina DRAGEN Secondary Analysis

University of Sydney

Kazusa DNA Research

Basepaws

製品のハイライト

DRAGEN analysis offers accurate, comprehensive, and efficient secondary analysis of next-generation sequencing data:
  • Continuous Innovation: Graph reference genome and machine learning driving unprecedented accuracy2
  • Hardware Acceleration: Provides ultra-efficient workflow; can fully process a 34x whole human genome in ~30 minutes with DRAGEN server v41
  • Lossless Compression: Furthers ultra-efficient workflow by reducing FASTQ file sizes up to 5× with DRAGEN ORA (Original Read Archive)
  • Broad Menu of Applications: Analyzes next-generation sequencing (NGS) data from whole genomes, exomes, methylomes, and transcriptomes
  • Flexible Configurability: Available on platform of choice and scalable based on needs

view video about Illumina DRAGEN – Accurate, Comprehensive, Efficient Secondary Analysis

Play Video

View Data Sheet

DRAGEN analysis offerings

DRAGEN On-Premise Server



DRAGEN Onboard



DRAGEN on Illumina Managed Cloud Platforms

Key Benefits

Accurate results

99.83% accuracy score with the Precision FDA Truth Challenge V2 benchmark data.3

Comprehensive platform

Analyze whole genomes, exomes, methylomes, and transcriptomes with a single platform.

Efficient analysis

Process a 34x genome in ~ 30 minutes, with all supported callers2. Reduce FASTQ file sizes up to 5× with DRAGEN ORA Compression.

DRAGEN secondary analysis achieving award-winning accuracy

DRAGEN analysis leads in accuracy for germline and somatic variant calling demonstrated in industry challenges from precisionFDA.

Harness the power of DRAGEN analysis

DRAGEN analysis enables labs of all sizes and disciplines to do more with their genomic data. DRAGEN analysis uses highly reconfigurable field-programmable gate array technology (FPGA) to provide hardware-accelerated implementations of genomic analysis algorithms, such as BCL conversion, mapping, alignment, sorting, duplicate marking, and haplotype variant calling. DRAGEN ORA lossless genomic compression technology enables significant storage cost savings on FASTQ files. Fundamental features of DRAGEN analysis address common challenges in genomic analysis, such as lengthy compute times and massive volumes of data.

Without compromising accuracy, DRAGEN analysis delivers quickness, flexibility, and cost efficiency. The reprogrammable nature of DRAGEN analysis enables Illumina to develop custom algorithms and allows for improvements to accommodate future applications.

Key DRAGEN applications

  On-Premise Server Onboard On Illumina managed cloud platforms
    NovaSeq X Series NextSeq 1000/2000 BaseSpace Sequence Hub Illumina Connected Analytics
BCL Convert         Custom only
DRAGEN ORA compression          
DRAGEN FASTQC + MultiQC          
Whole genome Germline + Somatic Germline only Somatic coming soon Germline only Germline + Somatic Germline + Somatic
Enrichment (including Exome) Germline + Somatic Germline + Somatic Germline + Somatic Germline + Somatic Germline + Somatic
DNA Amplicon          
RNA          
Single-Cell RNA          
Differential Expression          
NanoString GeoMx NGS          
RNA Amplicon         Coming soon
Methylation   Coming H2 2023      
Metagenomics  *        
RNA Pathogen Detection          
COVID COVIDSeq, COVID lineage   Cloud only COVIDSeq COVIDSeq, COVID lineage  
TSO 500 ctDNA available
Solid Coming Soon		      
Enabled in 3.10		  
Imputation          
ScATAC-Seq          
PGx Star Allele Caller   Coming soon      
Illumina Complete Long Reads          
DRAGEN Secondary Analysis for RPIP and UPIP panels Beta     Beta Beta

*Metagenomics applications enabled by Kmer classifier, more tools coming soon

Core DRAGEN version varies across platforms, speak to a local representative for more information

Download table document
Pipeline Description Variant Types Detected Metrics Provided
DRAGEN Demultiplexing Rapid demultiplexing of NGS analysis N/A N/A
DRAGEN Compression DRAGEN ORA compression is optimized for high compression ratios of FASTQ files, as well as rapid compression and decompression, all while preserving data integrity. N/A
  • Compression Ratio
  • Run Time
DRAGEN Map + Align The DRAGEN Map + Align can be run as a standalone or as part of DRAGEN’s suite of pipelines N/A
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
DRAGEN Germline The DRAGEN Germline Pipeline provides end-to-end NGS analysis, including advanced error model calibration for increased accuracy, and repeat expansion detection and genotyping through Illumina Expansion Hunter.
  • SNV
  • CNV
  • SV
  • Repeat Expansions
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
  • Variant Metrics
  • Callability Report
DRAGEN Somatic The DRAGEN Somatic Pipeline includes tumor-only and tumor–normal modes, designed for detecting somatic variants in tumor samples. Both modes make no ploidy assumptions, enabling detection of low-frequency alleles.
  • SNV
  • CNV
  • SV
  • TMB
  • MSI
  • HLA
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
  • Variant Metrics
  • Callability Report
DRAGEN Enrichment The DRAGEN Enrichment Pipeline combines DRAGEN’s germline and somatic callers into a pipeline designed specifically for analyzing enrichment samples. Includes a full suite of enrichment metrics and reporting.
  • SNV
  • CNV
  • SV
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
  • Variant Metrics
  • Callability Report
DRAGEN RNA The DRAGEN RNA Pipeline performs transcriptome analysis starting with splice junction discovery and alignment, followed by rapid alignment and splice junction mapping and quantification. For differential expression, Illumina recommends the DRAGEN Differential Expression app on BaseSpace Sequence Hub.
  • Gene fusion
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
  • Variant Metrics
  • Callability Report
DRAGEN Single Cell RNA The DRAGEN Single Cell RNA pipeline performs demultiplexing, cell-barcode and UMI error correction, sequence alignment, and quantification of gene expression. N/A
  • Mapping Metrics
  • Duration Metrics
  • Coverage Metrics
  • Callability Report
  • Cell Metrics
DRAGEN Joint Genotyping The DRAGEN Joint Genotyping/Population Pipeline calls variants jointly across multiple genomes and scales to large cohorts of samples at expedited speeds with uncompromising accuracy.
  • SNV
  • CNV
  • SV
  • Repeat Expansions
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
  • Variant Metrics
  • Callability Report
DRAGEN Methylation The DRAGEN Methylation Pipeline performs alignment, methyl calling, and calculates alignment and methylation metrics. N/A
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
  • Variant Metrics
  • Callability Report
DRAGEN Reference Builder Accepts FASTA files, and builds the proprietary reference used by the DRAGEN apps. N/A N/A
DRAGEN TruSight Oncology 500 ctDNA Analysis Software Secondary analysis support for Illumina’s TruSight Oncology 500 ctDNA. Only available on the local DRAGEN Server (version 3)
  • SNV
  • CNV
  • DNA fusions
  • MSI
  • TMB
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
  • Variant Metrics
  • Callability Report
DRAGEN Imputation The DRAGEN Imputation pipeline is an end to end user friendly tool that enables scalable low pass whole genome sequencing analysis N/A Impute ≤100 samples simultaneously 1.7x faster compared to original GLIMPSE code
SARS-CoV-2 NGS Data Toolkit

Illumina is making it simpler for researchers to detect and identify SARS-CoV-2 and contribute their findings to the community with an integrated software toolkit, free of charge.

Learn More
SARS-CoV-2 NGS Data Toolkit

DRAGEN analysis on Illumina managed cloud platforms

DRAGEN analysis on Illumina Connected Analytics couples the accuracy and speed of the DRAGEN with the ability to customize analysis pipeline to operationalize informatics on a secure platform.

Learn about Illumina Connected Analytics

DRAGEN on BaseSpace Sequence Hub (BSSH) provides push button analysis capability in an intuitive, easy-to-use interface with compliance, and storage features of BaseSpace Sequence Hub and Amazon Web Services (AWS).

Learn about BaseSpace Sequence Hub

DRAGEN on BaseSpace Sequence Hub
 

DRAGEN on-premise server

DRAGEN on-premise server offers highly accurate secondary analysis in a fraction of time compared with a traditional CPU-based system.

  • Analyze and store data locally
  • Supports varying levels of command line interface
  • Replace up to 30 traditional compute instances
  • Fully process a 34× whole human genome in ~30 minutes2. HG002 from PrecisionFDA truth challenge V2 run with DRAGEN analysis v4.0 on DRAGEN server v4, all callers
  • One unit supports two NovaSeq 6000 Systems running at full capacity

Read Data Sheet

DRAGEN On-Premise
 

DRAGEN onboard

DRAGEN onboard offers an accurate, comprehensive, and efficient secondary analysis solution for the NovaSeq X Series and NextSeq 1000/2000 Systems.

DRAGEN onboard NovaSeq X Series:

  • Flexibly runs multiple secondary analysis pipelines in parallel.
  • Performs up to four simultaneous applications per flow cell in a single run.
  • Brings up to 5x lossless data compression, and analysis with supported applications
  • Provides savings on analysis, which over five years can exceed the the price of the sequencer

Learn more about the NovaSeq X Series

DRAGEN onboard NextSeq 1000 and NextSeq 2000 Systems:

  • Provides access to select DRAGEN analysis informatics pipelines
  • Enables users to generate results in as little as two hours
  • Uses intuitive pipeline algorithms to reduce reliance on external informatics experts

Read Data Sheet

Customer Stories

 
Pioneering feline genetics with NGS

Basepaws, a Zoetis company, leverages the Illumina DRAGEN secondary analysis to develop direct-to-consumer DNA kits that provide cat owners with insights about their pets' health.

Read Interview
 
Scaling to the cloud to support whole-genome sequencing

Kyle Retterer, MS, Chief Technology Officer of GeneDx, discusses use of DRAGEN in the cloud to scale computing and data storage. This evolution brought more data analysis speed, infrastructure security, cost efficiency, and simplicity to their data management.

Read Customer Spotlight
 
Bringing bioinformatics in-house reduces costs and turnaround time

Phosphorus uses DRAGEN secondary analysis to perform genomic data analysis onsite and at an accessible price point.

Read Article
 
Can genomics stop cardiovascular disease?

Two DRAGEN servers help Cardio-CARE slay one petabyte of data to better understand heart disease in Hamburg.

Read Article

DRAGEN analysis uses

DRAGEN analysis can be used in numerous fields in the biological sciences.

Genetic Diseases

Reduce time required for genomic analysis, with high accuracy and comprehensiveness

Oncology

Analyze tumor-only and tumor/normal samples with accuracy, comprehensiveness, and efficiency

Cell and Molecular Biology

Advance understanding of cellular mechanisms with rapid analysis pipelines for bulk and single cell samples

Population Genomics

Accurately and efficiently analyze sequenced genomes at scale. Accelerate re-analysis as computational tools improve over time

Infectious Disease

Detect and characterize infectious diseases with a comprehensive solution

Agrigenomics

Efficiently analyze animals and plants of varying genomic complexities with custom reference

References
  1. Illumina data on file, 2022.
  2. Illumina DRAGEN Secondary Analysis is the first single platform to achieve 99.83% accuracy based on PrecisionFDA v2 Truth Challenge Benchmark Data. Details here.
  3. PrecisionFDA Truth Challenge V2: Calling Variants from Short and Long Reads in Difficult-to-Map Regions. precision.fda.gov/challenges/10. Accessed November 3, 2020.

よく一緒に購入される製品

Supporting Data and Figures

Flexible and Customizable Pipelines
DRAGEN Germline Pipeline Steps

DRAGEN analysis provides the flexibility to insert a variety of input files and produce a range of output documents. This flexibility enables users to customize their experience and use and produce their desired file format.

This diagram shows steps in the DRAGEN Germline Pipeline as an example. The actual steps vary for each pipeline.

製品資料

Basespace Sequencing Hub Apps Quick Guide

Brochure | PDF < 1 MB

Tumor exome sequencing with Illumina DNA Prep with Enrichment and the DRAGEN Platform

Application Note | PDF 1 MB

Integrating the Illumina DRAGEN Bio-IT Platform within your Infrastructure

Technical Note | PDF < 1 MB

DRAGEN Bio-IT Platform on BaseSpace Sequence Hub

Data Sheet | PDF 1 MB

DRAGEN Germline Pipeline Specification Sheet

Data Sheet | HTML

High-resolution, high-throughput spatial transcriptomics of complex tissues

Application Note | PDF 3 MB

High-plex spatial proteogenomics of FFPE tissue sections

Application Note | PDF 2 MB

Illumina Genomics Architecture enables PopGen studies with Illumina DNA PCR-Free Prep

Application Note | PDF 2 MB

Explore the transcriptome with single-cell resolution

Technical Note | PDF 1 MB

Technical Note | PDF | 3 versions

Technical Note | PDF | 2 versions

Data Sheet | PDF | 7 versions

マニュアルとサポート情報

DRAGEN Developer Resources Documentation

すべて DRAGEN  Support  

Related Products

BaseSpace Sequence Hub | クラウドベースのゲノムデータ管理
BaseSpace Sequence Hub | クラウドベースのゲノムデータ管理

次世代シーケンサー（NGS）の運用を開始し、急速に拡大するラボのためのデータ管理および簡素化されたバイオインフォマティクス。


Illumina Connected Analytics
Illumina Connected Analytics

インフォマティクスを運用し、科学的洞察を促進するための安全なゲノムデータプラットフォーム。


Clarity LIMS
Clarity LIMS

Clarity LIMSは、最適で効率的なラボ環境実現のために、ゲノミクスラボがサンプルを追跡しワークフローを管理できるよう設計されたラボ情報管理システムです。


関連ソリューション

トップに戻る  
本製品の使用目的は研究に限定されます。診断での使用はできません。
このページは機械翻訳を利用しております。なるべく正確な翻訳を提供するために合理的な努力をしていますが、完全に正確な翻訳とは限りませんので、あらかじめご了承ください。公式なコンテンツは英語版となります。

革新的なテクノロジー

イルミナは、遺伝多型と機能解析のための最新テクノロジーと革新的なアッセイを応用し、数年前は不可能であった研究を可能にすることを目標としています。私たちはお客様のニーズを満たすために、革新的で高い柔軟性と拡張性をもつソリューションをご提供することが必須であると考えています。グローバルカンパニーとして共同研究に価値をおき、迅速なソリューション、最高の品質を提供することに努めています。イルミナの革新的なシーケンスとアレイテクノロジーは、ライフサイエンス、トランスレーショナル研究、消費者ゲノミクス、分子診断の分野において画期的な進歩を支えています。

すべての商標および登録商標は、 Illumina, Inc または各所有者に帰属します。
商標および登録商標の詳細は jp.illumina.com/company/legal.htmlをご覧ください。

© 2023 Illumina, Inc. All rights reserved.