We’ve all heard the importance of exercise. Scientists study epigenetic changes in response to exercise. They observe genes upregulated after training was associated with decrease in DNA methylation. They also observe that methylation changes primarily occur in enhancer regions with enrichment for binding motifs for different transcription factors, indicating that training-induced epigenomic reprogramming targets enhancer regions. Sequencing technology today has given us the first epigenomic peeks into how our cells react to exercise. As our cells receive an exercise signal, a cascade of events occurs to respond to the external stimulus. Our epigenome immediately works to selectively turn on and turn off specific genes. For more information on applications of Illumina technology in the field of Epigenomics, please visit us at Illumina: Epigenomics http://www.illumina.com/applications/epigenetics.ilmn Products: HiSeq: http://www.illumina.com/systems/hiseq_2500_1500.ilmn Infinium 450K Methylation Array: http://www.illumina.com/products/methylation_450_beadchip_kits.ilmn Publication Links: PMID: 25484259 | Lindholm M.E., et al (2010): http://www.ncbi.nlm.nih.gov/pubmed/25484259 Publication Research Reviews: http://www.illumina.com/science/publications/publications-review.ilmn The Science Mondays (SciMon) series is brought to you by Illumina http://www.illumina.com/ Illumina hosts Swati Kadam, Ph.D., Scientific Liaison, Scientific Affairs and Jacques Retief, Associate Director Scientific Affairs deliver 5 minutes of scientific enlightenment on the latest discoveries.