製品

Illumina DRAGEN Bio-IT Platform

The Illumina DRAGEN (Dynamic Read Analysis for GENomics) Bio-IT Platform provides accurate, ultra-rapid secondary genomic analysis of sequencing data. Read More...
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DRAGEN CS Lvl 1 1 year License

20027361

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DRAGEN CS Lvl 2 1 year License

20027362

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DRAGEN CS Lvl 3 1 year License

20027363

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DRAGEN CS Lvl 4 1 year License

20027364

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DRAGEN CS Lvl 5 1 year License

20027365

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Illumina DRAGEN Server v3

20040619

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Illumina DRAGEN Bio-IT Platform

Illumina DRAGEN Bio-IT Platform

BioIT 2018

GeneDx

Xing Cancer Care

製品のハイライト

The Illumina DRAGEN Bio-IT Platform offers:
  • Accurate data: Detects small variants with high analytical sensitivity and specificity1
  • Lossless genomic compression: Reduces FASTQ file sizes up to 5X with DRAGEN ORA (Original Read Archive) lossless compression
  • Robust speed: Processes an entire human genome at 30× coverage in about 25 minutes2,3
  • Frequent releases: Includes releases of regular enhancements and upgrades
  • Various applications: Analyzes next-generation sequencing (NGS) data from whole genomes, exomes, and RNA

The Illumina DRAGEN Bio-IT platform and data submission apps on BaseSpace Sequence Hub also support the SARS-CoV-2 Data Toolkit. Learn More.

DRAGEN Options

DRAGEN on BaseSpace Sequence Hub

DRAGEN on Illumina Connected Analytics

DRAGEN On-Premise

DRAGEN on NextSeq 1000/2000

Key Features

Ultra-Rapid Secondary Genomic Analysis

The DRAGEN Platform can process NGS data for an entire human genome at 30× coverage in about 25 minutes on premise vs. > 15 hours with a traditional CPU-based system. It set two world speed records for genomic data analysis.2,3

Cost-Efficient Solution

When run on Illumina's BaseSpace Sequence Hub or Illumina Connected Analytics, analysis for a 30x genome is ~$5/sample and an exome at 100x coverage ~$3/sample.

Highly Accurate Results

In the 2020 PrecisionFDA Truth Challenge V2, DRAGEN won Difficult to Map Regions and All Benchmark Regions on Illumina Sequencing data.1

Diverse Applications

The DRAGEN Platform analyzes sequencing data from a variety of experiment types, including whole genomes, whole exomes, germline and somatic datasets, and RNA sequencing experiments.

Lossless Genomic Compression

DRAGEN ORA (Original Read Archive) compression technology is optimized for high compression ratios of FASTQ files, as well as rapid compression and decompression, all while preserving data integrity.

Frequent Updates

Frequent releases continuously expand and improve the DRAGEN Platform while accommodating new applications and addressing evolving industry standards. DRAGEN updates are version controlled, enabling users to opt in or out of new updates as desired.

DRAGEN Wins Key Categories in PrecisionFDA Truth Challenge V2

The DRAGEN team at Illumina is excited to announce winning Best Performance in the Difficult to Map Regions and All Benchmark Regions on Illumina Sequencing data. This win marks the start of major new capabilities that will be improved to include structural variants, copy number variations, and repeat expansions. Our success shows that we can now call variants with better accuracy than what was thought possible in difficult to map regions.

Learn More

Harness the Power of the DRAGEN Platform

The DRAGEN Platform enables labs of all sizes and disciplines to do more with their genomic data. The DRAGEN Platform uses highly reconfigurable field-programmable gate array technology (FPGA) to provide hardware-accelerated implementations of genomic analysis algorithms, such as BCL conversion, mapping, alignment, sorting, duplicate marking, and haplotype variant calling. DRAGEN ORA lossless genomic compression technology enables significant storage cost savings on FASTQ files. Fundamental features of the DRAGEN Platform address common challenges in genomic analysis, such as lengthy compute times and massive volumes of data.

Without compromising accuracy, the DRAGEN Platform delivers quickness, flexibility, and cost efficiency. The reprogrammable nature of the DRAGEN Platform enables Illumina to develop custom algorithms and allows for improvements to accommodate future applications.

Key DRAGEN Applications

  DRAGEN server BaseSpace Illumina Connected Analytics NextSeq 1000/2000
Demultiplexing (BCL Convert)        
DRAGEN ORA lossless genomic compression        
Map & Align        
Whole genome (germline & somatic)       Germline only
Exome enrichment (germline & somatic)        
COVIDSeq        
RNA Pathogen Detection        
RNA-Seq (gene fusion & quantification)        
Single-Cell RNA        
Joint Genotyping        
Methylation        
TSO 500 Liquid        
Metagenomics        

DRAGEN is also available via an Amazon Machine Image (AMI) on AWS MarketPlace

Pipeline Description Variant Types Detected Metrics Provided
DRAGEN Demultiplexing Rapid demultiplexing of NGS analysis N/A N/A
DRAGEN Compression DRAGEN ORA compression is optimized for high compression ratios of FASTQ files, as well as rapid compression and decompression, all while preserving data integrity. N/A
  • Compression Ratio
  • Run Time
DRAGEN Map + Align The DRAGEN Map + Align can be run as a standalone or as part of DRAGEN’s suite of pipelines N/A
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
DRAGEN Germline The DRAGEN Germline Pipeline provides end-to-end NGS analysis, including advanced error model calibration for increased accuracy, and repeat expansion detection and genotyping through Illumina Expansion Hunter.
  • SNV
  • CNV
  • SV
  • Repeat Expansions
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
  • Variant Metrics
  • Callability Report
DRAGEN Somatic The DRAGEN Somatic Pipeline includes tumor-only and tumor–normal modes, designed for detecting somatic variants in tumor samples. Both modes make no ploidy assumptions, enabling detection of low-frequency alleles.
  • SNV
  • CNV
  • SV
  • TMB
  • MSI
  • HLA
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
  • Variant Metrics
  • Callability Report
DRAGEN Enrichment The DRAGEN Enrichment Pipeline combines DRAGEN’s germline and somatic callers into a pipeline designed specifically for analyzing enrichment samples. Includes a full suite of enrichment metrics and reporting.
  • SNV
  • CNV
  • SV
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
  • Variant Metrics
  • Callability Report
DRAGEN RNA The DRAGEN RNA Pipeline performs transcriptome analysis starting with splice junction discovery and alignment, followed by rapid alignment and splice junction mapping and quantification. For differential expression, Illumina recommends the DRAGEN Differential Expression app on BaseSpace Sequence Hub.
  • Gene fusion
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
  • Variant Metrics
  • Callability Report
DRAGEN Single Cell RNA The DRAGEN Single Cell RNA pipeline performs demultiplexing, cell-barcode and UMI error correction, sequence alignment, and quantification of gene expression. N/A
  • Mapping Metrics
  • Duration Metrics
  • Coverage Metrics
  • Callability Report
  • Cell Metrics
DRAGEN Joint Genotyping The DRAGEN Joint Genotyping/Population Pipeline calls variants jointly across multiple genomes and scales to large cohorts of samples at expedited speeds with uncompromising accuracy.
  • SNV
  • CNV
  • SV
  • Repeat Expansions
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
  • Variant Metrics
  • Callability Report
DRAGEN Methylation The DRAGEN Methylation Pipeline performs alignment, methyl calling, and calculates alignment and methylation metrics. N/A
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
  • Variant Metrics
  • Callability Report
DRAGEN Reference Builder Accepts FASTA files, and builds the proprietary reference used by the DRAGEN apps. N/A N/A
DRAGEN TruSight Oncology 500 ctDNA Analysis Software Secondary analysis support for Illumina’s TruSight Oncology 500 ctDNA. Only available on the local DRAGEN Server (version 3)
  • SNV
  • CNV
  • DNA fusions
  • MSI
  • TMB
  • Mapping metrics
  • Duration Metrics
  • Coverage Metrics
  • Variant Metrics
  • Callability Report

Bringing Bioinformatics In-House Reduces Costs and Turnaround Time

Alexander Bisignano, cofounder and Chief Executive Officer of Phosphorus, discusses how the company uses the DRAGEN Bio-IT Platform to perform genomics data analysis onsite and at an accessible price point.

Read Interview
SARS-CoV-2 NGS Data Toolkit

Illumina is making it simpler for researchers to detect and identify SARS-CoV-2 and contribute their findings to the community with an integrated software toolkit, free of charge.

Learn More
SARS-CoV-2 NGS Data Toolkit

DRAGEN on Illumina analytics platforms

DRAGEN on BaseSpace Sequence Hub or Illumina Connected Analytics couples the speed and accuracy of the DRAGEN platform with the security, cost savings, and intuitive interface of our software platforms.

  • Push-button analysis for varying levels of expertise
  • Stream data directly from instruments for rapid analysis
  • Low costs with no hardware investments
  • Leverages the security, compliance, and storage features of BaseSpace Sequence Hub and Amazon Web Services (AWS)

Learn about BaseSpace Sequence Hub

Learn about Illumina Connected Analytics

DRAGEN on BaseSpace Sequence Hub
 

DRAGEN On-Premise

DRAGEN on-premise conducts secondary analysis in a fraction of the time compared with a traditional CPU-based system, while still maintaining high accuracy.

  • Analyze and store data locally
  • Supports varying levels of command line interface
  • Replace up to 30 traditional compute instances
  • Process NGS data for an entire human genome at 30x coverage in < 25 minutes
  • One unit supports two NovaSeq 6000 systems running at full capacity

Read Data Sheet

DRAGEN On-Premise
 

DRAGEN Onboard NextSeq 1000/2000

The on-board DRAGEN Bio-IT Platform offers an ultra-rapid, accurate solution for secondary analysis.

  • Access to select DRAGEN informatics pipelines
  • Enables users to generate results in as little as two hours
  • Provides optimized, hardware-accelerated algorithms for a wide variety of genomic analysis solutions, including BCL conversion, mapping, alignment, sorting, duplicate marking, and variant calling
  • Uses pipeline algorithms to reduce reliance on external informatics experts

Read Data Sheet

DRAGEN Use Cases

View Video
The Broad Institute

Collaborators Anthony Philippakis from The Broad Institute, and Susan Tousi of Illumina, discuss how integration of GATK with Illumina sequencers and implementation of the DRAGEN Platform may facilitate hardware acceleration and standardization of data analysis.

View Video
 
Learn About the Illumina/Broad Partnership
GeneDx Scales from Exomes to Genomes using DRAGEN

Leveraging DRAGEN, GeneDx is now able to grow its operations while keeping costs low, turnaround times short, and accuracy high.

Read Article
Rady Children’s Hospital

A Guinness world record was set for Fastest Genetic Diagnosis in 19.5 hours. The DRAGEN Platform was used to significantly increase the speed of mapping and aligning genomic data once sequenced.1

Read Article
Xing Cancer Care

See how Basespace Sequence Hub and DRAGEN have simplified NGS data analysis for this lab.

Watch Video

Read Article

DRAGEN Applications

The DRAGEN Platform can be used for numerous applications in the biological sciences.

Population Sequencing

Rapidly analyze the sequenced genomes; accelerate reanalysis as computational tools improve over time.

NICU and Genetic Disease Research

Reduce time required for genomic analysis, when fast results can be a critical factor.

Cancer Research

Accurate, rapid analysis of tumor-only and tumor/normal samples.

Agrigenomics

Analyze animals and plants of varying genomic complexities, using a provided reference.

Clinical and Translational Research

Analyze targeted exome data with rapid turnaround and high accuracy to ensure reproducibility and high-quality results.

References
  1. PrecisionFDA Truth Challenge V2: Calling Variants from Short and Long Reads in Difficult-to-Map Regions. precision.fda.gov/challenges/10. Accessed November 3, 2020.
  2. Bio IT World. Children’s Hospital Of Philadelphia, Edico Set World Record For Secondary Analysis Speed. October 23, 2017. www.bio-itworld.com/2017/10/23/childrens-hospital-of-philadelphia-edico-set-world-record-for-secondary-analysis-speed.aspx. Accessed September 19, 2018.
  3. The San Diego Union Tribune. Rady Children's Institute sets Guinness world record. February 12, 2018. www.sandiegouniontribune.com/news/health/sd-no-rady-record-20180209-story.html. Accessed September 19, 2018.

Frequently Purchased Together

Supporting Data and Figures

Flexible and Customizable Pipelines
DRAGEN Germline Pipeline Steps

DRAGEN provides the flexibility to insert a variety of input files and produce a range of output documents. This flexibility enables users to customize their experience and use and produce their desired file format.

This diagram shows steps in the DRAGEN Germline Pipeline as an example. The actual steps vary for each pipeline.

製品に関する文献

Integrating the Illumina DRAGEN Bio-IT Platform within your Infrastructure

Technical Note | PDF< 1 MB

Tumor exome sequencing with Illumina DNA Prep with Enrichment and the DRAGEN Platform

Application Note | PDF1 MB

Application Note | HTML | 5 versions

Basespace Sequencing Hub Apps Quick Guide

Brochure | PDF< 1 MB

DRAGEN Bio-IT Platform on BaseSpace Sequence Hub

Data Sheet | PDF1 MB

DRAGEN Germline Pipeline Specification Sheet

Data Sheet | HTML

Data Sheet | PDF | 5 versions

マニュアルとサポート情報

すべて DRAGEN Bio-IT Platform Support 

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