詳細
Although it has been widely accepted that the protein expression level is simply determined by the abundance of mRNA, by recent genome-wide and comprehensive analysis, mRNA could only explain 30-40% of protein abundance in cells. Given the impact of translation control to the final proteome in cells, monitoring protein synthesis in vivo has been a demanding task, however, has posed the analytic hurdle. To overcome the issue, a technique called ribosome profiling based on next-generation deep sequencer was developed and indeed enables us to survey translation and its regulation in vivo. In this webinar, I would like to introduce tips, tricks, and tweaks of ribosome profiling and the powerful and versatile applications to such as anti-tumor translational inhibitors and ribosome collisions.
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- 日時
- 2021/07/15
- 3:00 PM - 4:00 PM
- Location
- Japan
- Asia
- Presenter
- 理化学研究所開拓研究本部 主任研究員
東京大学大学院新領域創成科学研究科メディカル情報生命専攻
岩崎 信太郎 先生 - Topic
- Cellular & molecular biology