COVID-19 Host Genetics & Immune Response Profiling


Investigating COVID-19 Host Genetics

Uncovering the underlying factors that contribute to host susceptibility and immune response is essential to unravel the complexities of COVID-19. It is crucial to understand how genetic variance contributes to susceptibility as well as define how the immune system responds during the course of the disease. Illumina genomics solutions allow researchers to interrogate host genetic variance and profile the molecular mechanisms that drive immune responses.

The key benefits of using Illumina technology for studying the immune response to COVID-19 include:

  • Scalability to screen diverse sample sets
  • Solutions to enable a multi-omic approach to understand host genetics and immune response
  • Analysis solutions to match your project scale

Methods for Host Risk & Immune Response Studies

Application Goal Recommended Methods
Host genetics research
  • Define host genetic risk factors
Host immune response profiling
  • Understand biology/mechanism of immune response
  • Identify biomarkers for disease progression
Microbiome & host response
  • Study effect of microbiome in COVID patients
Illumina to Sequence Genomes for New UK-wide COVID-19 Study
Data from severely ill patients may help us understand the genetics of susceptibility.
Webinar: COVID-19 Host Genetics Initiative

Mark Daly, PhD discusses a global effort to identify host genetics contributions to COVID-19 disease susceptibility and severity.

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Using Genomics to Study COVID-19 Host Genetic Variability

Dr. Lee Murphy’s core lab at the University of Edinburgh applies a genomic approach to study host genetic variability in disease progression and outcome in SARS-CoV-2 hospitalized patients. The team and collaborators perform genotyping and WGS on DNA samples, as well as mRNA-Seq on the NextSeq 2000 System.

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Collaborative Environment for COVID-19 Host Response Research
BaseSpace Correlation Engine enables and accelerates COVID-19 research.

Featured Host Genetics & Immune Response Publications

High-throughput SARS-CoV-2 and host genome sequencing from single nasopharyngeal swabs
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Presence of Genetic Variants Among Young Men with Severe COVID-19
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COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis
Read Paper
Get help finding the right solutions for your host genetics and immune response studies.

Related Solutions

Microbiome Analysis

The study of microbial communities found in and on the human body allows researchers to understand the role of microbes in health and disease.

Shotgun Metagenomics

A DNA sequencing method that enables comprehensive sampling of all genes in all organisms in a given complex microbial sample.

Complex Disease Research

Complex diseases result from a combination of genetic and environmental factors. Array and sequencing technologies can help reveal the underpinnings of these diseases.

Cell & Molecular Biology

Expand cell and molecular biology research beyond conventional methods with next-generation sequencing.

Single-Cell RNA-Seq

With single-cell RNA-Seq, researchers can study cellular differences that are often masked by bulk sampling.